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Indeed, brain hub regions in humans do exhibit a spatiotemporally distinctive transcriptomic pattern dominated by genes associated with metabolic processes, including those with oxidoreductase activity (e.g., GPx) (Xu et al., 2022)

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APAP induces hepatotoxicity, attenuates lipid peroxidation, and enhances antioxidant enzyme activation, including increases in interleukin (IL)-1β, IL-6, and tumor necrosis factor-α elevated (Yen et al., 2008)